五毒门乃江湖上一恶名远扬的门派，老掌门靠药浴维系残年，身边只有一个弟子杨得（江生饰）。有感本门恶事作尽，老掌门命杨得清理本门门户，并寻找其师叔的宝藏。杨得的五位师兄分别习练五种由毒虫而来的武功，分别是：蜈蚣（鹿峰饰）、蛇（韦白饰）、蝎子（孙建饰）、壁虎（郭追饰）、蛤蟆（罗莽饰）。 nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs;杨得乔装成乞儿，迤逦打探到一座县城，巧遇隐姓埋名的师叔老夫子一家遭人灭门，凶手正是大师兄与二师兄，虽然本县何捕头凭习练蛤蟆功的五师兄助拳将大师兄拿获，但县令与二师兄勾结反将五师兄下狱害死。三师兄时常蒙面夜会二师兄，掌控全局于幕后。 nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs;杨得发现何捕头即四师兄后向对方亮明身份，两人决定合力清除大师兄二师兄。暗处的三师兄决定出手了……