超级病毒“金美拉”和抗生素在运送途中，被恐怖组织头目Sean Amose（ Dougray Scott nbs;饰）盗走，Ethan Hunt（Tom Cruise 饰）率领他的IMF小组接受中情局的任务，找回病毒。 nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs;这次，Ethan Hunt找到了女飞贼Nyah Nordoff-Hall（Thandie Newton nbs;饰）搭档，后者是Sean Amose的前女友。Ethan Hunt在获取Nyah信任的同时，二人也暗生情愫。 nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs;但是，为了完成任务，Ethan Hunt不得不安排Nyah回到Sean Amose身边卧底。 nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs;Nyah终于打探出病毒所在的药厂，接获情报的Ethan Hunt前往药厂准备销毁病毒；另一边，Sean Amose已经察觉出了Nyah回到自己身边的真正目的，组织人马在药厂等待Ethan Hunt自投罗网。 nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs; nbs;激烈的搏斗中，Nyah为了帮助Ethan Hunt完成任务，将病毒注入了自己体内，只有在20个小时之内将抗生素注入Nyah体内，才能挽救她的性命，Ethan Hunt又将面临不可能的任务。